Monday, January 25, 2010

project 1 abstract

The concept for my project is to create a product that works in conjunction with the idea of salivary diagnostics. Salivary diagnostics is the diagnosis and screening for an enormous variety of diseases, cancers and other illnesses. Though the technology is not yet completed and perfected, it should be a legitimate and realistic way to more accurately test for ailments within the next 10-15 years. Salivary diagnostics works several different ways. One is by inputting a sample of saliva into a mass spectrometer. The mass spectrometer then passes a laser beam through the sample and identities various proteins by recognizing their structure according to a protein map developed by scientists. Another way is a reactive solid that detects the presence of immunoglobins (the things that indicate disease) and visually shows a difference to the tester. Yet another is via samples tested in electrophoresis gels. My product is a conceptual piece, aiming to utilize this future technology. The toothbrush would have a small cartridge that collects saliva and activates a sensor when an abnormality or risk is detected. Then, the cartridge would be sent or taken to a doctor or dentist equipped with a mass spectrometer to be analyzed. I think salivary diagnostics is a FASCINATING idea that could hugely benefit society. If recognition of warning signs is available in the home, it is more likely that people will be able to catch diseases in their earliest onsets. Many people are afraid of visiting a doctor, afraid of blood tests or too awkward for other tests (invasive to various orifices) and this system would solve the entire problem. This could be especially helpful in detecting juvenile onset of diabetes or obesity, and perhaps in the future data could be added to recognize necessary changes in eating habits and nutrition. This product is related to the food network in that dental and physical health are dependent upon and influence the food we eat.



here are some links and research that i have found

http://www.ada.org/public/topics/saliva_diagnostics.pdf

http://www.progenosis.com/index.php

Combination of Reverse Transcriptase PCR Analysis and Immunoglobulin M Detection on Filter Paper Blood Samples Allows Diagnostic and Epidemiological Studies of Measles

Rik L. De Swart,1,* Yassin Nur,1 Abdallah Abdallah,1 Hans Kruining,1 H. Sittana El Mubarak,2 Salah A. Ibrahim,2 Bernadette Van Den Hoogen,1 Jan Groen,1 and Albert D. M. E. Osterhaus1

Institute of Virology, Erasmus Medical Centre Rotterdam, 3000 DR Rotterdam, The Netherlands,1 and Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan2

Received 20 July 2000/Returned for modification 29 September 2000/Accepted 18 October 2000

As measles control and elimination campaigns progress, laboratory confirmation of clinically diagnosed measles cases becomes increasingly important. However, in many tropical countries collection and storage of clinical specimens for this purpose are logistically complicated. In this study it is shown that blood samples spotted on filter paper are suitable for the laboratory diagnosis of measles using a combination of reverse transcriptase PCR (RT-PCR) analysis and immunoglobulin M (IgM) detection. First, it was shown that in vitro measles virus (MV)-infected cells diluted in human blood and spotted on filter paper can be detected by RT-PCR. Small amounts of infected cells remained detectable after 25 weeks of storage of the filter paper at room temperature, 4 weeks at 37°C, or 2 weeks at 45°C. Subsequently, this RT-PCR was applied to filter paper blood samples collected from 117 clinically diagnosed measles patients in Sudan in 1997 and 1998. Prior laboratory diagnosis had confirmed 90 cases as acute MV infections, while 27 proved to be nonmeasles rash disease cases. Positive RT-PCR signals were detected in filter paper blood samples of 43 of the 90 confirmed cases (48%) but in none of the 27 nonmeasles cases. In addition, MV-specific IgM levels measured in reconstituted filter paper samples correlated well with those measured in plasma samples. Measles diagnosis based on the combination of filter paper RT-PCR and IgM detection had a sensitivity and specificity of 99 and 96%, respectively. An advantage of this diagnostic approach is that sequencing of RT-PCR products allows phylogenetic analysis of the MV strain involved.


Sunday, January 24, 2010

looks kind of like what everrrrryone is doing...

http://itechfuture.com/garden-concept-breathe/

potentially clever?

http://gizmodo.com/5360755/stealthy-colgate-ad-ruins-ice-cream-forever

Saturday, January 23, 2010

hahahahahahahahah

http://pics.blameitonthevoices.com/012010/bread_gloves.jpg

interesting.

these are interesting concepts...

http://www.designaddict.com/design_addict/blog/index.cfm/2009/11/26/Save-food-from-the-refrigerator

Tuesday, January 19, 2010

Expert Interview

The most important thing that the majority of parents don’t understand is that the form and frequency of the sugars are the most important in preventing tooth decay.
Sitting down and drinking an entire bottle of Coca Cola within 5 minutes is infinitely better for one’s teeth than sipping it over a period of several hours
Each time ANY CARBOHYDRATE is introduced to the mouth system, bacteria on the tooth’s surface eats the sugars. The waste product of this bacteria is acid and acid eats away the enamel of the tooth. Weakened enamel=super susceptible to cavities
Parents think that “natural” or “organic” forms of sugar are less destructive to children’s teeth, THIS IS TOTALLY FALSE!!! Giving a child a honey stick, or a fructose sweetened cookie is EXACTLY THE SAME as handing them a snickers bar
Fructose, lactose, sucrose, etc. are all sugars, thus they have the same effect in the mouth
Raisins and fruit leathers are of the worst “healthy” snacks to give to children-they are sticky and get lodged in hard to clean out areas and easily cause carries and cavities
Giving a child a bottle of milk at night is terrible because the salivary and muscular defense systems slow down significantly at night so it is like a constant drip of harmful sugar into the mouth
The only verbal communication that children have as infants is to cry and scream. Parents often calm them with a bottle or food. This teaches the child that FOOD=COMFORT and that food is a way to cope with trauma
It also prevents children from properly developing means to cope. Children NEED to cry and scream to be able to develop their own coping mechanisms.
Pacifiers and bottles change the shape and impedes growth of lower jaw and prevents it from developing the way the parents’ genetics intended, the jaw doesn’t calcify and solidify until age 22
Form follows function- if you put a shape there, the mouth will conform to it..example: Chinese foot binding
Water with fluoride in it is BEST
Teeth that develop without fluoride DO NOT FORM CORRECTLY they are jagged and sharp with grooves and fissures. Contrary to teeth that develop WITH fluoride, the non-fluoridated teeth are not self cleaning. Teeth developed with fluoride ARE self-cleaning.
Fluoridated enamel is less soluble in acid than hydroxolated (non fluoridated) enamel
Cavities and carries from when tooth enamel goes into solution
Baby teeth lead the way for permanent teeth
Sports drinks are especially harmful…not totally sure why, but hypothesized that because salivary activity significantly slows during exercise which means that the body’s natural defense (saliva) isn’t present
Also, some ingredient in them might be more harmful. Also, “gu,” energy candies, and power bars consumed during exercise are terrible for teeth.
Most people disassociate the teeth from the rest of their body and don’t realize that it is one of the most important systems that works in concert with your body.

Monday, January 11, 2010

This is hilarious yet really tragic simultaneously. I think I could handle the giant sushi roll....mmmmmm.. It's strange though how celebrated these HUGE portions are. Everything is bigger...bigger....and BIGGER. What about quality? I feel like so many are focused on gigantic portions that they lose sight of savoring truly delicious morsels of food. On the other hand though, some of these projects ended up feeding the needy or raising money for charities.

http://webecoist.com/2009/11/30/super-size-it-the-world%E2%80%99s-largest-food/

I can't get the website to turn into a link, but the web address is posted above.

Wednesday, January 6, 2010

First blog post....ever!

http://www.charmcitycakes.com/

I LOVE the show on Food Network "Ace of Cakes" featuring Charm City Cakes. Their work is so fascinating and looks like so much fun!